The sensitivity analysis functions on globularized fraction of α lamellae were established using a physically-based microstructure model and gradient method. These functions were applied to the sensitivity analysis on globularized fraction of α lamellae in TC17 alloy. The material constants in these functions are determined using the genetic algorithm-based objective optimization technique. The globularized fraction of α lamellae during isothermal compression of TC17 alloy was quantitatively analyzed based on scanning electron microscopy (SEM) observation. (nhnhanh)